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Thomas Brenn

Melanocytic  tumours – update on epidemiology and molecular biology

Handout (pdf, 120p)

Handout (pdf, 30p)

Abstract:

Melanoma is a heterogeneous disease group with a wide morphological and clinical spectrum. Its correct diagnosis may be challenging and relies almost entirely on the interpretation of the histological features. Furthermore the behaviour of melanoma may be difficult to predict, and, at least until recently, treatment options were largely limited to surgery with little benefit form adjuvant therapies. Over the last two decades significant progress has been made in our understanding of the underlying complex genetic and molecular events in melanoma, further highlighting the genetic heterogeneity and diversity of the disease and showing good correlation with the histological features. These molecular findings have had a significant impact as a diagnostic aid, and they have led to the development of targeted therapies. This talk will provide an overview of the spectrum of melanoma and the recent developments in the field with particular emphasis on their value and relevance in clinical practice.

CV

Dr. Thomas Brenn is a graduate from the Ruprecht-Karls University of Heidelberg, Germany. After postdoctoral fellowships in the Departments of Genetics and Pathology at Stanford University, CA, USA and residency training in Anatomic Pathology at the Brigham and Women’s Hospital in Boston, MA, USA, he pursued subspecialty fellowships in Dermatopathology and Soft Tissue Tumour Pathology. In 2003, Dr. Brenn joined the faculty of the Brigham and Women’s Hospital and Harvard Medical School and was a consultant in pathology at Dana Farber Cancer Institute. In 2007, he was made Head of Dermatopathology at NHS Lothian University Hospitals Trust and Honorary Senior Lecturer at the University of Edinburgh, Scotland. Dr. Brenn is the current Chair of the Skin Working Group of the European Society of Patology (ESP) and Chief Examiner for the RCPath Diploma in Dermatopathology. He is also a member of the steering committee of the National Specialist EQA scheme in Dermatopathology and served on the executive committee of the British Society for Dermatopathology. He has contributed to major textbooks in Dermatology as well as Dermtopathology and is a co-editor of the 4th edition of McKee’s Pathology of the Skin. His clinical and research interests relate mainly to the pathology of cutaneous soft tissue tumours, skin adnexal tumours as well as melanocytic tumours.

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KONXION A/S